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医療データ科学の実践

医療データ科学のスタッフは、医療データ科学の方法論の研究のみならず、多様な疾患領域の医学研究に共同研究者等の立場で参画し、研究デザインとデータ解析を担当することで医学研究に貢献しています。以下は、教室スタッフがこれまでに関与した医学研究の一部です。様々な疾患、様々なタイプの研究が含まれています。

  • Ishizu K, Takahashi S, Kouno N, Takasawa K, Takeda K, Matsui K, Nishino M, Hayashi T, Yamagata Y, Matsui S, Yoshikawa T, Hamamoto R. Establishment of a machine learning model for predicting splenic hilar lymph node metastasis. NPJ Digit Med. 2025; 8(1): 93.
  • Okita M, Takenaka K, Hirai F, Ashizuka S, Iijima H, Bamba S, Fujii T, Watanabe K, Shimodaira Y, Shiga H, Hiraoka S, Inokuchi T, Yamamura T, Emoto R, Matsui S. Diagnostic accuracy and cut-off values of serum leucine-rich alpha-2 glycoprotein for Crohn’s disease activity in the small bowel. J Gastroenterol. 2025; 60(5): 573-582.
  • Okita M, Nakashima K, Yamamura T, Matsui S. Systematic review and meta-analysis of the use of serum leucine-rich alpha-2 glycoprotein to assess Crohn’s disease activity. Inflamm Bowel Dis. 2024; 30(5): 780-787.
  • Emoto R, Nishikimi M, Shoaib M, Hayashida K, Nishida K, Kikutani K, Ohshimo S, Matsui S, Shime N, Iwami T. Prediction of pre-hospital change of the cardiac rhythm from non-shockable to shockable in out-of-hospital cardiac arrest patients: a post hoc analysis of a nationwide, multicenter prospective registry. J Am Heart Assoc. 2022; 11(12): e025048.
  • Kumagai S, Togashi Y, Kamada T, Sugiyama E, Nishinakamura H, Takeuchi Y, Vitaly K, Itahashi K, Maeda Y, Matsui S, Shibahara T, Yamashita Y, Irie T, Tsuge A, Fukuoka S, Kawazoe A, Udagawa H, Kirita K, Aokage K, Ishii G, Kuwata T, Nakama K, Kawazu M, Ueno T, Yamazaki N, Goto K, Tsuboi M, Mano H, Doi T, Shitara K, Nishikawa H. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies. Nat Immunol. 2020; 21: 1346-1358.
  • Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Matsuda C, Nakamoto Y, Kotake M, Kurachi K, Egawa T, Yasumasa K, Murata K, Ikawa O, Shinji S, Murotani K, Matsui S, Teramukai S, Tomita N, Sugihara K; SACURA Study Group. Prospective multicenter study on the prognostic and predictive impact of tumor budding in stage II colon cancer: Results from the SACURA trial. Journal of Clinical Oncology 2019; 37: 1886-1894.
  • Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Resuscitation 2019; 140: 135-141.
  • Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M. [Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a. Neuron 2019; 101: 60-75.
  • Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S. Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice. Free Radic Res. 2018; 52: 1030-1039.
  • Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N. Effect of administration of ramelteon, a melatonin receptor agonist, on the duration of stay in the ICU: A single-center randomized placebo-controlled trial. Critical Care Medicine 2018; 46: 1099-1105.
  • Takagishi M, Sawada M, Ohata S, Asai N, Enomoto A, Takahashi K, Weng L, Ushida K, Ara H, Matsui S, Kaibuchi K, Sawamoto K, Takahashi M. Daple coordinates planar polarized microtubule dynamics in ependymal cells and contributes to hydrocephalus. Cell Reports 2017; 20: 960-972.
  • Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T, Higashi M, Umino H, Makishi G, Numaguchi A, Matsushima S, Tokuyama H, Nakamura M, Matsui S. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy. Intensive Care Medicine 2016; 42: 2106-2107.
  • Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H. Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: an exploratory descriptive study using a nationwide claims database. Journal of Epidemiology 2017; 27: 373-380.
  • Sugimoto T, Matsumoto T, Hosoi T et al. Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT). Osteoporos Int. 2015; 26: 765-774.
  • Negoro H, Kanematsu A, Doi M et al. Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun. 2012; 3: 809.
  • Shoji S, Suzuki M, Tomono Y et al. Population pharmacokinetics of pregabalin in healthy subjects and patients with post-herpetic neuralgia or diabetic peripheral neuropathy. Br J Clin Pharmacol. 2011; 72: 63-76.
  • Yamaguchi K, Mandai M, Oura T et al. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. Oncogene 2010; 29: 1741-1752.
  • Watanabe D, Suzuma K, Matsui S et al. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med. 2005; 353: 782-792.